The OS of the 34 patients was 57.9% at five years, and themedian survival duration was 77 months. By receiver operatingcharacteristic curve analysis, the threshold values of thegreatest diameter of the metastatic pulmonary tumor, ageat the time of diagnosis of metastatic disease, and DFI, whichpredicted death with the highest sensitivity and specificitywere ≥25-mm, ≥60 years, and ≤26 months, respectively. Bysingle variable analysis, histology of squamous cell carcinoma(SCC) (P = 0.005), age ≥60 years (P = 0.003), and DFI≤26 months (P = 0.001) were associated with a poor prognosis(Table 3). Furthermore, a ≥25-mm maximum tumordiameter tended to be associated with a shorter survival thana <25-mm maximum tumor diameter, though the differencedid not reach statistical significance (P = 0.075). The cumulativeOS curves constructed by the Kaplan–Meier method,and compared, using the log-rank test, are shown inFigure 1a and b. Using multiple variable analysis, a DFI ≤26months (hazard ratio [HR] 3.396; 95% confidence interval[CI] 1.133–10.177; P = 0.018), and age ≥60 years (HR 3.256;95% CI 1.023–10.360; P = 0.046), were independentpredictors of adverse outcomes (Table 4). The five-year OSrate of patients ≥60 years of age and whose DFI was ≤26months was 0%, while in patients in whom a single orneither criterion was met, the five-year survival was 74.5 ±9.0% (Fig 2).
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