Milk fat contains a large amount of saturated FAs and is considered energy dense, which on a dietary basis are generally linked with an increase in risk factors of CVD and increased risk of obesity (Kratz et al., 2013). However, a large part of milk fat is SCFA and MCFA, which we identified to be the highly potent inducers of ANGPTL4 in intestinal cells. The results presented here may contribute to broaden the view of saturated FA present in milk fat and its effect on obesity.