The production of pasta filata cheeses using a mix-ture of ewe or goat milk could be an interesting and feasible opportunity for the dairy industry of Southern Italy, allowing its expansion in the market. Regard-ing this opportunity, the development of appropriate technologies for the production of innovative and re-formulated cheeses, aimed at obtaining products with proper characteristics and satisfactory acceptance by consumers, is of particular interest. The goal of this study was to develop innovative Caciocavallo cheeses made from a mixture of ewe or goat milk with cow milk. The achieved cheeses were assessed for their physico-chemical, microbiological, and sensorial characteristics through a comparison with traditional Caciocavallo cheeses made from cow milk