HBO up to 1 hour reperfusion significantly reduced the number of leukocytes sticking to the endothelium(above) and inhibited the progressive vasoconstriction arterioles adjacent to venules (below) compared to reperfused ischemic nontreated vessels.( 39)
arteriolar vasoconstriction, deterioration of the microcirculation preparation after 3 hours obviated the addition of delayed HBO treatment groups. It is likely that the timing of HBO therapy in relation to I-R injury is important in producing a beneficial response.