For certain study participants for whom stabilization of blood
pressurewas difficult, itwas important to have the capacity to collaborate
with a physician to titrate doses of diuretic and to alter
times of medication administration. One participant required
changes to the timing of medications including taking his ACE
inhibitor and a diuretic in the morning, a calcium channel
blocker at noon, and a second dose of the ACE inhibitor in the
evening. By combining different antihypertensive medications
at different times of the day, blood pressure was lowered without
the participant experiencing precipitous drops in pressure
experienced when allmedications were taken at the same time.