DNA Flow Cytometry Analysis. UV treatment of skin f ibroblast cells resulted in cell cycle alterations, specifically in the suppression of G0/G1 phase progression and induction of S and G2/M phase arrest. Treatment of UVB-exposed cells with pomegranate polyphenolics decreased the UVB-induced cell cycle arrest in S phase and partially restored the suppressed G0/G1 progression (Figure 4); however, these effects were not significant. Cell cycle perturbations in UVAexposed skin fibroblast cells remained unchanged (p < 0.05) following treatment with pomegranate polyphenolics (data not shown).