In conclusion, we demonstrate beneficial effects of anthocyanin supplementation on metabolic disorders in subjects with type 2 diabetes. The protective mechanism by anthocyanin on diabetes was closely correlated with prevention of dyslipidemia, lower systemic oxidative damage, and an increase in insulin sensitivity. Furthermore, there were no effects and no adverse events were reported. Therefore, anthocyanin supplementation has the potential to overcome the metabolic aberrations that are associated with diabetes in humans.