Arsenic (As)exertsoxidativestresswithdepletionofbodyseleniuminmonogastricanimals.But in ruminants this fact is not yetverified.VitaminE is an effective dietary antioxidant.Thus,inthisexperiment the protective effect of vitaminE against arsenic toxicity induced by sodium arsenite(60mgAs/kgdiet)
was investigated in goat kids.For this,21male kids were divided into three equal groups and fed either
basal diet as such(control),or supplemented with 60mgAs/kg diet and 60mg As/kgdiet+250IU vitamin
E/kg diet for180 days VitaminE supplementation alleviated the toxic effects caused by arsenic on serum
alanine aminotransferase and aspartate aminotransferase and lipid peroxidation It also prevented the
depletion of reduced glutathione content and reduction in activity of catalase, superoxide dismutase and
glutathione-s-transferase in erythrocytes resulted from arsenic intoxication Theอelevated levels of arsenic
and reduced levels of selenium in the serum and tissues in arsenic treated animals were attenuated by
vitamin E supplementation,though not completely.However,serum cortisol level was not affected by
arsenic. It was concluded that arsenic exerts cortisol independent stressor mechanism and supplementation of vitaminE at a level of 250 IU/kg diet was partially effective in reducing tissue accumulation of
arsenic in the body and protect the kids from oxidative stress induced by arsenic.