Background: In Bombyx mori, the genes responsible for silk biosynthesis appear to be controlled by hormones.
Results: Bmdimm is specifically expressed in silk glands and directly regulates the expression of fibroin H-chain (fib-H) by the juvenile hormone (JH)-Met-Kr-h1 pathway.
Conclusion: JH is involved in synthesis of fib-H through Bmdimm.
Significance: This pathway provides new insights into hormonal regulation of silk protein genes.