AGE Effective Where Anti-Hypertensive Drugs Failed Investigators at the University of Adelaide in Australia showed for the first time that AGE can treat hypertension more effectively than medication. The study, published in 2010 in the Journal Maturitas, was a randomized, double-blinded placebo controlled trial of 50 patients whose high blood pressure did not respond to anti-hypertensive drugs.
The patients were adults with systolic blood pressure of 140 mm Hg or higher and diastolic pressure of 90 mm Hg or above. They were all being treated with conventional antihypertensive medications and instructed not to change the prescribed medications during the trial. Twenty five patients received four capsules a day, containing a total of 960 mg of odorless AGE and 2.4 mg S-allyl cysteine, for 12 weeks. This daily dose was equivalent to an intake of 2.5 mg of fresh garlic. Twenty-five control patients received a placebo of similar capsules, devoid of AGE. Blood pressures were monitored at baseline and at 4.8 and 12 weeks. Patients were reminded to keep taking their usual prescribed antihypertensive medicines.