These events are influenced by the residence of cell body of an axotomized neuron within the peripheral nervous system or CNS, location of axonal trauma in relation to the cell body, and maturity of the nervous system at the time of injury. Peripheral neurons regenerate their axons more readily than central neurons after axotomy, and the more proximal the injury is to the cell body, the greater the likelihood of neuronal death. Furthermore, in the immature brain and spinal cord, axotomized neurons often die much more rapidly than adult maturity-related effect on the rate of neuronal degeneration are not understood, but the signal transduction mechanisms of neuronal apoptosis are different in immature and mature neurons (32).