Platinum® Taq DNA Polymerase is recombinant Taq DNA polymerase
complexed with a proprietary antibody that blocks polymerase activity at
ambient temperatures. Activity is restored after the denaturation step in
PCR cycling at 94°C, thereby providing an automatic “hot start” for Taq
DNA polymerase in PCR (1,2,3). Hot starts in PCR provide increased
sensitivity, specificity, and yield, while allowing assembly of reactions at
room temperature. The use of this antibody helps reduce PCR optimization
requirements, reaction set-up time and effort, handling of reaction
components, and contamination risk.