Nile tilapia is freshwater fish with economic important Since it is a highly nutritious source of protein. The consumption of Tilapia in Thailand Thai up to 30% of all fish. And a higher consumption trends continue. Tilapia Fish consumption in Thailand is not enough fish to market demand. But the major problems affecting the aquaculture is the disease. Which can occur for many reasons, such as raising density, water quality during breeding, feeding. Including fish poor quality enough to cause disease. The disease has several types of diseases caused by protozoa, fungi, viruses and bacteria. The bacteria that cause disease in animals, including Aeromonas sp., Lactococcus sp., Enterococcus sp., Vagococcus sp., Streptococcus sp.