Human echinococcosis is a cosmopolitan zoonosis caused by larval stage of the cestode parasite, Echinococcus granulosus. Although the liver is the most frequently involved site, the cysts can develop in almost all organs of the body. The diagnosis mainly depends on radiological and immunological techniques, although recently molecular biology techniques have also been applied. Thus, routine laboratory diagnosis of CE is heavily reliant on serological tests by antibody and antigen but the circulating hydatid antigen is present in an active or recent infection and is absent in patients treated with surgery or chemotherapy. The detection of the circulating antigen is useful in detecting hydatid disease in antibody-negative patients and also in assessing the status of the infection. The serum is generally used as a specimen for immunological tests. However, the collection of blood samples can be problematic, particularly in remote rural areas and being an invasive procedure may be hazardous and unsafe in untrained hands.