Due to the undesirable physiological effects caused by a high concentration
of BAs in sensitive humans, many efforts have been performed in order to reduce their concentration in various foods. In particular, the consumption of foods with high-level concentration of histamine can have vasodilation effects1 in humans as well as cause headaches, heart palpitations,edema, vomiting, diarrhea and other symptoms2; thus, there are great demands to reduce the histamine concentration in the preparation of fermented foods.