In this research, novel composite scaffolds consisting of silk fibroin and forsterite powder were prepared by afreeze-drying method. In addition, the effects of forsterite powder contents on the structure of the scaffolds were in vestigated to provide an appropriate composite for bone tissue engineering applications. The morphology studies using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques showed that the forsterite ceramic was well distributed throughout the structures of SF/forsterite scaffolds. Furthermore, the forsterite powder (upto40wt %) was homogenously distributed within the silk fibroin as a matrix. Crown Copyright & 2013 Published by Elsevier Ltd and Techna Group S.r.l. All rights reserved.