Seligman’s (2011) PERMA theory of well-being describes a multi-dimensional approach in order to define what it means to flourish in life. The PERMA constructs include Positive emotion (P), Engagement (E), Relationships (R), Meaning (M), and Accomplishment (A). Butler and Kern (2014) developed the PERMA-Profiler, a brief measure of PERMA. In this study, we extend the PERMA-Profiler to a Malaysian sample, in order to examine how well the measure works in another culture. Participants (N = 322) completed the PERMA-profiler, and subset of participants (n = 268) also answered two qualitative questions about their perspectives on well-being. We compared the sample means to data previously collected from participants in the United States (N = 5,456). The Malaysian sample was significantly lower than the US sample on all of the PERMA domains Next, we used factor analysis to examine the proposed five-factor structure. A three-factor model (positive emotion/ relationships, meaning/accomplishment, and engagement) fit the data better than the proposed five factors. We then coded and examined the qualitative questions on perceptions of well-being. While the PERMA constructs were generally represented, there were also other constructs that went beyond the PERMA model, such as religion, health, and security. Examining the PERMA-Profiler in Malaysia provides the opportunity to understand well-being more comprehensively in different cultures and evaluate how individuals in specific cultures flourish.