The ethanolic leaf extracts of 30 medicinal plants were tested for their cytotoxicity against human breast adenocarcinoma cell line (MCF 7), human hepatocarcinoma cell line (HepG2) and human cervix adenocarcinoma cell line (HeLa). The cytotoxicity was evaluated by performing MTT assay, trypan blue exclusion assay and morphological assessment under phase contrast inverted microscope. For the extracts which tested positive, IC50 (the concentration that inhibited cell growth by 50%) was calculated. The extract(s) were further subjected to Thin Layer Chromatography (TLC) to determine their phytochemical profile.