The diflunisal was given in an initial dose of two tablets (500 mg) followed
by one tablet twice a day, as recommended by the manufacturers. After
five days the patient complained of mild pruritus, pale stools, and dark urine.
His pain had been well controlled. On examination he was found to be
clinically jaundiced and apyrexial. There was no lymphadenopathy; chest and
heart were normal; the abdomen was soft with no enlargement of gall
bladder, liver, or spleen; rectal examination disclosed only pale stools; and
urine cortained bilirubin. Cholestatic jaundice was diagnosed and diflunisal
stopped. He continued to take the indomethacin