The objectives of this study are: 1) to study the present management of hotel business in Phitsanulok Province, Thailand. 2) to study the satisfactions and needs of foreign guests about hotel management in Phitsanulok, and 3) to propose guidelines for hotel management in Phitsanulok. This study used mixed research methods including both quantitative and qualitative tools. Qualitative methodology used structured interview with government officials and hotel owners and the outcome had been analyzed as content. Quantitative methodology used questionnaire with the foreign guests. General information was analyzed by using descriptive statistics describing percentages. Information on satisfactions and needs gathered of hotel management in Phitsanulok was analyzed by using mean (X) and standard deviation (S.D.). The results revealed that the context of hotel management in Phitsanulok Province, Thailand is performed on the basis of cooperation between public sector and the hotel owners both directly and indirectly by controlling and formatting as a group because both parties have same the goal as being a potential tourist attractions in Thailand and also in preparation for the ASEAN Economic Community. In the 5 criteria of the market model of a hotel industry, foreign guests were satisfied with the price of hotels in Phitsanulok at the highest level, followed by location, facilities, services, and image respectively. For the needs of foreign guests in hotel management in Phitsanulok, price ranked the first, followed by facilities, services, location, and image respectively.