Recently, our studies suggest a potential of the polymeric blends between chitosan, that is derived from shrimp shell, and starch for acting as a rate-controlling matrix. As we know, chitosan is derived from chitin which is found in a wide range of natural sources such as exoskeleton of crab and shrimp, and pen of squid. However, only few studies have so far discussed the effects of chitosan sources on film properties. In this study, therefore, we prepared the hydrogel patch from the chitosan or the blended chitosanstarch to deliver curcuminoids compound to the skin. The chitosan used is derived from various sources including crab shell, shrimp shell or squid pen. The curcuminoids powder was first prepared in oil-in-water (o/w) microemulsion before being incorporated into the aqueous solution of the chitosan or the blended chitosanstarch. This was processed to improve the water miscibility and the hydrolytic stability of the curcuminoids powder]. To prove this idea, physicochemical properties and stability of the developed hydrogel patch for incorporating curcuminoids microemulsion were investigated and the release rate and pattern of curcumin from such patch were elucidated. Additionally, the determination of skin irritation after single application of the curcuminoids hydrogel patch in volunteers was investigated.