For example, hypermethylation of promotors in GABAergic neurons may contribute to the phenotypic
remodelling responsible for schizophrenia and bipolar disorder [15].
Given that many of these diseases have also been linked to Vitamin D
deficiency, it is not surprising tofind that Vitamin D can modulate the
epigenetic landscape and this may contribute to its ability to maintain phenotypic stability. This regulation of the epigenome by
Vitamin D depends on its ability to induce the expression of a number
of key DNA demethylases such as JMJD3, LSD1 and LSD2 [16]