In present, Number of people with disabilities have a lot more.(Data from the National Statistical Office, Thailand, 2007) The problem of disability is physical, mental and social. For example, normal activities can not be discouraged, disappointed and depressed. Our survey of Phukrang District , Praputhabat Saraburi experience found more than 50% depression. The importance of the research has established the health promotion program with humanized care on depression of people with mobility disabilities to lead to lower levels of depression.