On 3 October, Agüero scored five goals against Newcastle United in a 6–1 comeback win, joining Andy Cole, Alan Shearer, Jermain Defoe and Dimitar Berbatov in scoring as many in a Premier League game.[160] His five goals within 23 minutes of game time made it the fastest five-goal haul since the Premier League started in 1992.[161] Four minutes after scoring his fifth goal in the 62nd minute, Agüero was substituted by manager Manuel Pellegrini as he had been receiving treatment due to a leg injury at half time.[162]