ABSTRACT
Objective: To understand the impact of platelet associated immunoglobulin G (PAIgG)/
platelet associated immunoglobulin M (PAIgM) on severity of dengue virus infection
leading to thrombocytopenia.
Methods: In this study we examined a total of 52 patients who were having secondary
infection of dengue in acute phase by using competitive ELISA.
Results: A decrease in the platelet count was observed at the acute phase of infection
while all along the recovery stage the count of platelet was significantly increased. A
significant decrease was observed in PAIgG and PAIgM in these subjects. Inverse correlation
was found between platelets count and PAIgG/PAIgM among the subjects
studied. In the platelets elution from ten subjects, anti-dengue virus immunoglobulin G
and immunoglobulin M were observed. PAIgG and PAIgM with inclined levels were
higher in dengue hemorrhagic fever than the classical dengue fever. In the development
of dengue hemorrhagic fever PAIgM inclined level was independently associated with
high specificity, showing a possible indication of dengue hemorrhagic fever.
Conclusions: This study suggests that in secondary dengue virus infection, the PAIgG
and PAIgM levels, and the activity of anti-dengue virus play key roles, both in the
development and severity of the disease.