Paper made of cellulose fibres is naturally hydrophilic and
allows penetration of aqueous liquids within its fibre matrix. This
property provides the foundation for using paper to fabricate
microfluidic systems [1]. It has been reported that paper-based
microfluidic devices can be built by demarcating hydrophilic paper
by walls of hydrophobic polymers [2]. Following this principle,
Martinez et al. [2,3] explored the use of a photolithography method
to create microfluidic channels in paper by making hydropho-
bic barrier walls in the paper matrix. Hydrophobic photoresist
polymers provide a very good physical barrier, which defines the
liquid penetration pathways into paper. A liquid sample can be
directed into multiple detection zones where indicators have been
deposited. This device demonstrates the possibility of the simul-
taneous detection of multiple analytes in a liquid sample. The
barrier-design microfluidic systems are well suited for making
health care and telemedicine devices. However, this fabrication
method has two potential deficiencies: first, the hardened photore-
sist barrier is susceptible to the damage from bending and folding.
Second, photolithography requires expensive equipment and the
fabrication process has multiple steps. There is a need for alterna-
tive and more efficient fabrication methods.
Paper made of cellulose fibres is naturally hydrophilic andallows penetration of aqueous liquids within its fibre matrix. Thisproperty provides the foundation for using paper to fabricatemicrofluidic systems [1]. It has been reported that paper-basedmicrofluidic devices can be built by demarcating hydrophilic paperby walls of hydrophobic polymers [2]. Following this principle,Martinez et al. [2,3] explored the use of a photolithography methodto create microfluidic channels in paper by making hydropho-bic barrier walls in the paper matrix. Hydrophobic photoresistpolymers provide a very good physical barrier, which defines theliquid penetration pathways into paper. A liquid sample can bedirected into multiple detection zones where indicators have beendeposited. This device demonstrates the possibility of the simul-taneous detection of multiple analytes in a liquid sample. Thebarrier-design microfluidic systems are well suited for makinghealth care and telemedicine devices. However, this fabricationmethod has two potential deficiencies: first, the hardened photore-sist barrier is susceptible to the damage from bending and folding.Second, photolithography requires expensive equipment and thefabrication process has multiple steps. There is a need for alterna-tive and more efficient fabrication methods.
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