This large cross-sectional, multi-center study evaluated the association of body composition measurements by a novel dual frequency bio-impedance device (BIA-ACC) with chronic stress/inflammation biomarkers and presence of Medically Unexplained Symptoms (MUS).
MATERIALS AND METHODS:
Participants were adult Caucasians of both sexes and included 10416 lean subjects with no MUS (Group A), 58710 lean subjects with MUS (Group B) and 30445 overweight/obese subjects with no MUS and excessive Fat Mass (FM) (Group C).
RESULTS:
Total body extracellular water (ECW) was lower, while intracellular water (ICW) was greater in Group A than both other groups (p<0.01). Group A had significantly lower FM and higher skeletal mass (SK) and phase angle (PA) than Group B and lower circulating high sensitivity (hs)CRP levels than both other groups. hsCRP was higher in Group C than Group A (p<0.01). Salivary cortisol in Group A was higher in the morning and lower in the evening than both other groups (p<0.001), indicating circadian rhythm obliteration or reversal. ECW correlated positively with hsCRP and 8pm cortisol, but negatively with 8am cortisol and PA, while PA correlated positively with 8am and negatively with 8pm cortisol, 8 am hsCRP and 8 am and 8 pm salivary cortisol correlated to presence of MUS and BIA-ACC measurements, including ECW, ICW, FM, SK and PA.
CONCLUSIONS:
MUS is an index of chronic stress and inflammation and BIA-ACC may provide a useful, bloodless and rapid tool in the clinical setting, distinguishing patients with chronic stress/inflammation from healthy subjects and monitoring their response to treatment. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
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