In summary, neuropeptides may well have a role in the acute and
preventive therapy of migraine headache. Among the different neuropeptides,
at present only CGRP seems to be a possible target for migraine
therapy. Currently, the safety issues of the CGRP-receptor
antagonists limit their use, but antibodies targeting CGRP or its receptors
seem to be valuable candidates for migraine prevention in the
near future.