The present study was carried out to investigate the anti-inflammatory and antioxidant and properties of ethanol extract of Crinum asiaticum (Syn: Crinum
amabile) leaf. The carrageenan induced paw edema model was used to evaluate the anti-inflammatory activity in Wister albino rats. In this study, Crinum
asiaticum leaf extract was administered to animals at the dose of 2gm/kg and 1gm/kg body weight and the obtained effects were compared with commercially
available anti-inflammatory drug diclofenac sodium (10 mg/kg) for carrageenan induced paw edema test. Antioxidant activity of theCrinum asiaticum ethanol
leaf extract was assessed by DPPH free radical scavenging method. Crinum asiaticum leaf extract showed significant effect in the reduction of the paw edema
induced by carrageenan at the dose of 2gm/kg and 1gm/kg body weight where 40.8% and 8.76% of paw edema were reduced at the 4
th hour of administration
of extract. These results indicate that Crinum asiaticum leaf extract have potent anti-inflammatory effect. Leaf extract also showed DPPH free radical
scavenging effect compared with ascorbic acid. IC
50
value of ascorbic acid and leaf extract was found 13.26mg/ml and 71.4mg/ml respectively