Phosphoinositide phosphates are membrane components that participate in the early steps of signaling cascades. Phosphoinosite-3,4,5-triphosphate (PIP3) is one of the most important members of this family (Fruman et al., 1998). When produced in the cell membranes, it recruits proteins that contain a pleckstrin homology (PH) domain, such as AKT and PDK-1 that in turn initiate signaling pathways that control important cellular functions including cell proliferation, cell motility, metabolism,and survival.