In intention-to-treat analysis, Poisson regression
analysis, which incorporates more of the follow-up
information than the time-to-event analysis (ie, total
number of cancers in follow-up period vs time to fi rst
cancer), showed similar estimates of the protective eff ect
but, as anticipated, greater statistical signifi cance. The
per-protocol analysis showed a similar eff ect.
In intention-to-treat analysis, Poisson regressionanalysis, which incorporates more of the follow-upinformation than the time-to-event analysis (ie, totalnumber of cancers in follow-up period vs time to fi rstcancer), showed similar estimates of the protective eff ectbut, as anticipated, greater statistical signifi cance. Theper-protocol analysis showed a similar eff ect.
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