Interventions Given the positive impact of osteoporosis medications on fracture prevention, low risk of drug–drug interactions and low incidence of adverse effects, they should not be considered ‘inappropriate prescriptions’ in older patients. There is a significant relationship between increasing age and decreasing likelihood of receiving effective osteoporosis treatment. Selection of an appropriate medication includes consideration of dose, frequency, route of administration, adverse effects, adherence, costeffectiveness and ability to prevent fractures early. mproving medication persistence irrespective of the drug is an important goal to ensure efficacy.