Interestingly, the mammalian organs that consume the most glucose, namely , brain and muscle , carry out very little glucose synthesis. The major sites of gluconeogenesis are the liver and kidneys,whitc account for about 90% and 10% if the body's gluconeogenesis, respectively. Glucose produced by gluconeogenesis in the liver and kidney is released into the blood and is subsequently absorbed by brain, heart ,muscle and red blood cell to meet their metabolic needs. In turn.