The sericin protein present on the outer surface of fiber creates problem in regeneration process. The presence of sericin affects the solubility of fibroin in various solvent for dope preparation. Therefore, it should be completely removed from fibroin surface. The process of removal of sericin is known as degumming. The sericin is removed from the surface of fibroin by boiling the silk cocoon in 0.02 M sodium carbonate solution for 30-40 min. [Min et al.(2009)] Another method to remove the sericin from the surface of fibroin is to pressure boil via autoclave. The complete removal of sericin canbe achieved by boiling the cocoon at 130°C for 1 hour. [Gulrajani et al. (2009)]