0:00the active ingredient in Zillah par is so large a lien
0:03a selective irreversible inhibitor above
0:06Melb what differentiates develop our from conventional solar Julian
0:11is designed this delivery technology which actually alters the
0:15pharmacokinetic profile is allegedly
0:17let's first look at how conventional so literally in works
0:23following oral administration about seventy-three percent
0:26have the administered dose of conventional solar Julian is absorbed
0:30through the gastrointestinal tract
0:31and undergoes extensive first-pass metabolism in the liver
0:35solo Julian's primary metabolites are
0:38des Smyth also a Julian amphetamine and methamphetamine
0:42these metabolites are pharmacologically active
0:45and some research suggests that the amphetamine like metabolites
0:49maybe no toxic and cardio toxic for example patients taking conventional so
0:54what Julian
0:54may experience insomnia or restlessness
0:58following first pass metabolism the bioavailability of conventional so what
1:03Julian
1:03is only about 10 percent meaning that only about 10 percent of the
1:07administered dose passes into the bloodstream
1:10unchanged continuing its journey to the brain maximum plasma concentrations are
1:15achieved in
1:1640 to 90 minutes
1:19in the brain conventional sledge alene binds to
1:22and inactivates MA OB inhibiting the metabolism of dopamine
1:26as a result more dopamine is available to facilitate the process of
1:31neurotransmission
1:40develop our tablets are
1:42formulated using design disorderly dissolving tablets Oro DT technology
1:46one placed on top of the Tom the apartheid was
1:50disintegrate within seconds and a rapidly absorbed through the buccal
1:54mucosa
1:55because the lebara voice for first pass metabolism
1:58the relative bioavailability Afzal a par is approximately
2:03six to eight times that of conventional soldiering
2:06meaning that more active drug is alternately delivered
2:09to the bloodstream in pharmacokinetic studies
2:13plasma levels were up to four times higher after a single
2:172.5 milligram dose apps on a par compared to five milligrams conventional
2:22solar Julian given twice daily
2:24zella par achieves maximum plasma concentration within 10 to 15 minutes
2:29versus 40 to 90 minutes for conventional soldiering
2:34in addition the concentration of them fed a mean like metabolites scene was on
2:38a par
2:39is greatly reduced
2:42zone apart
2:43vers more active drug to the bloodstream faster than conventional soldiering
2:47effectively inhibiting Melb and increasing the level of dopamine in the
2:51brain
2:52as demonstrated in clinical trials so far provides a robust
2:57symptomatic benefit reducing of time by 2.2 hours per day
3:02and increasing disclosure free on time
3:05by 1.8 hours per day