Hierarchical
clustering analysis (HCA) was performed on the scaled frequency
data of these gene-overlapping CNVs to group the most similar
population together based on frequencies. Although these CNVs
were picked to highlight the difference between Thai and
HapMap3 populations, the populations that showed the closest
relationship to Thais were JPT, CHB, and CHD (Figure 3). Based
on the HCA results, Asian populations were still the most similar
to each other. Populations with European and African ancestries
from HapMap3 samples were placed in a different clade from
Asian populations. Hence, cautions should be taken when
interpreting CNVs found in the Thai population using CNV
databases created based on subjects with European or African
ancestry.