Bispecific antibodies (BsAb) can, by
virtue of combining two binding
specificities, improve the selectivity
and efficacy of antibody-based
treatment of human disease. Recent
studies underline the importance
of both the ‘anti-trigger’ and
‘anti-target’ modalities of BsAb for
therapeutic efficacy. Several BsAb
induce effective cytotoxicity as well
as ‘vaccine effects’ in vivo. Here,
Annemiek van Spriel and colleagues
discuss how these results have
catalysed renewed efforts to
translate BsAb concepts into
effective therapies.