Both the more-affected, trained and the less-affected, untrained lower limb of patients from TG showed marked gains in power and dynamic force. This crosseducation effect occurs in individuals with stroke after ECC or ECC-overload, but not CON RE [12, 33], underlining the potential role of ECC muscle actions in facilitating central nervous system adaptations. Stroke compromises neural drive to skeletal muscle, and is manifested in neuromuscular dysfunction of both the more- and less-affected limbs [34]. It is plausible that the unique neural command required to execute ECC muscle actions [21] provides a powerful stimulus to counteract this effect.