Patients and methods
The study involved 15 patients (4 men), mean age 51.8±15.3 years, mean BMI value -
24.7±3.5, with thyrotoxicosis due to Graves’ disease or toxic multinodular goitre. Serum
sclerostin was measured by immunoassay at diagnosis of thyrotoxicosis and after 6–10 weeks
of treatment with thiamazole. The data were analysed by means of simple descriptive
statistics of location and dispersion and Mann–Whitney U test for pairs of results, before and
after thiamazole therapy. Association between variables was evaluated with use of
Spearman`s correlation coefficient.