The animal experiment was conducted in accordance with a protocol (IACUC#
37115) approved by the Institutional Animal Care and Use committee at the
Pennsylvania State University (University Park, PA, USA). Male C57BL/6 J mice (4
weeks old) were purchased from Jackson Laboratories (Bar Harbor, ME) and
maintained on 12 h light/dark with access to food and water ad libitum. After a 2-
week acclimatization period, mice were randomized to LF diet (n=23), HF diet (n=21)