In the present study, we investigated the possibility of bioethanol production from oil palm empty fruit bunches. The purpose of the study was to construct a pilot-scale plant and integrate all processes such as pretreatment, hydrolysis, fermentation, and purification. The potential amount of ethanol production from EFB was determined on the basis of the pilot-plant operation. Finally, this study determined the mass balance of bioethanol production from 500 kg EFB.