Another investigation with the results supporting the possible
antagonism between Pb and Cd was carried out on bank voles,
animals that are good model for environmental exposure. Animals
were exposed for 6 weeks to dietary Cd and Pb (Cd-60; Pb-300; Cd-
60 + Pb-300 μg/g dry weight-concentrations 2-fold higher than those
expected in high contaminated areas). No significant changes in liver
concentrations of toxic metals, TBARS or GSH levels were observed
between groups treated with a single metal and a group
treated with a mixture (Salin´ ska et al., 2012).
Having in mind reproductive and developmental toxicity of Pb
and Cd, investigations on the effects of their co-exposure are of
special concern. The effect of Pb and Cd mixture in the period of
pregnancy and lactation was examined in female Wistar rats receiving
300 mg Pb/L, 10 mg Cd/L, or 300 mg Pb/L + 10 mg Cd/L in
drinking water from day 1 of pregnancy to parturition or until