ASSESSMENTS
Cognitive assessments
At baseline only, all participants were administered a four subtest
version of the Wechsler Adult Intelligence Scale-Third Edition
(WAIS-III) (consisting of Arithmetic, Similarities, Picture Completion
and Digit Symbol subtests) as an estimate of current IQ, and
the Wechsler Test of Adult Reading (WTAR) as an estimate of
premorbid intelligence. Additional cognitive assessments were
performed at baseline and at the end of 6 and 13 weeks of
treatment for all patients. Working memory, verbal fluency,
attention/perceptual-motor processing speed and verbal memory
were assessed using the WAIS-III Letter-Number Sequencing (LNS),
the Controlled Oral Word Association Test (COWAT) letter
fluency, Form A of the Trail Making Test (TMT-A) and Logical
Memory I and II (LMI and LMII) of the Wechsler Memory Scale
Revised, respectively. Identical versions of LNS and TMT-A and
alternate versions of the COWAT letter fluency and LMI and II were administered at each assessment. TMT-A was incorporated into
the battery after initiation of the trial, which resulted in a lower
total number of patients completing this measure.