Iron Chelators
Exposure of the skin to UV radiation results in high
intracellular iron levels, favoring the production of reactive
oxygen species; this finding is the basis for including iron
chelators in photoprotective products.69 N-(4-pyridoxy/
methylene)-l-serine (PYSerine), an antioxidant whose
action is mediated by iron sequestration, has been shown to attenuate UV-B radiation-induced skin damage in mice:
its topical application resulted in a histologic reduction
in epidermal hyperplasia and lymphocyte infiltrates
and inhibited the production of glycosaminoglycans
in the dermis, thereby reducing and delaying wrinkle
formation.69