As hemodialysis can readily counteract propylene glycol toxicity in patients, a low protein binding may be assumed [80]. In this study dialysis was used to reduce exposure (serum concentration) to propylene glycol in a critically ill patient with acute renal failure, given lorazepam. Propylene glycol is an alcohol of small molecular weight (76.1 daltons). This type of agent bears several properties which favor excellent clearance by hemodialysis, including small size, non-ionic state, high water solubility and lack of significant protein binding.