The antinociceptive activity of MeOH extract of A. ilicifolius was tested by using three models (acetic acid-induced, formalin and hot plate) so that both the centrally and peripherally mediated effects could be investigated. The acetic acid-induced pain involves the peripheral mechanism whereas the hot plate test involves the central mechanism (20, 21). The formalin test is believed to show the involvement of both peripheral and central mechanisms (22).