Coccidiosis, an enteric disease caused by the genus Eimeria, results in severe economicloss higher than USD 10 billion annually in the world due to reduced production efficiencyand increased treatment costs [1–3]. There are seven Eimeria spp. that can infect chickens,and each Eimeria spp. colonizes different parts of gastrointestinal tracts and exhibits negative impacts on chickens with different modes of actions [4]. Eimeria tenella resides inthe epithelial cells of cecal crypts in broilers and modulates cecal functionality [5]. Eimeria tenella infection is known to reduce growth performance, mainly feed efficiency [6],induce oxidative stress [7], induce inflammatory response [8], and modulate gut barrier integrity [9] in broilers. Eimeria tenella is known to be one of the most pathogenic Eimeria spp.that causes high morbidity and mortality in broiler chickens [10].