Alpha-lipoic acid (ALA) in its oxidized form is a coenzyme
involved in the bioxidation of pyruvates. The reduced form of ALA,
dihydrolipoic acid, is a powerful mitochondrial antioxidant [5]. ALA
is considered an important antioxidant that may be of therapeutic
value in some pathologic conditions related to the overproduction of
oxidant radicals [6]. ALA is an essential cofactor for mitochondrial
enzymes and a natural antioxidant that is used to quench free radicals
[7]. ALA has valuable potential in clinical interests as a cellular thiolreplenishing
and redox-modulating agent [8]. The reduced form
of ALA, dihydrolipoic acid, reacts with oxidants such as superoxide
radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals,
and singlet oxygen and minimize the cellular damage effects