Multiple-trigger wheeze has been defined recently by a European Respiratory Society task force to describe children who wheeze both during and outside discrete episodes. The treatment of preschool children with multiple-trigger wheeze with ICS appears to be more successful than that of children with episodic viral wheeze. Children with multiple-trigger wheeze often develop symptoms after crying, laughter or exercise. Based on these findings, many believe that multiple-trigger wheeze resembles allergic asthma, but there is little direct evidence to support this. It remains unknown whether the histopathology of the airways from children with multiple-trigger wheeze resembles that of allergic asthma. However, a proportion of preschoolers with persistent wheeze do develop asthma in later life