In post-Civil War Wyoming, John "The Hangman" Ruth (Russell) is escorting fugitive Daisy "The Prisoner" Domergue (Leigh) to Red Rock where the latter will face justice for murder. They encounter another bounty hunter named Major Marquis "The Bounty Hunter" Warren (Jackson) and Chris "The Sheriff" Mannix (Goggins). A blizzard forces the four to take shelter at a stagecoach passover called Minnie's Haberdashery where they encounter four more strangers; Bob "The Mexican" (Bichir), Oswaldo "The Little Man" Mobray (Roth), Joe "The Cow Puncher" Gage (Madsen), and ex-General Sanford "The Confederate" Smithers (Dern). Through betrayal and deception, the eight strangers soon learn that they may not make it to Red Rock after all.